Which part of the nephron does NOT have epithelial cells throughout?

The thin ascending limb of the loop of Henle is the portion of the nephron that does not have epithelial cells throughout its entire structure. Unlike other segments of the nephron that are lined with a continuous layer of epithelial cells, the thin ascending limb primarily consists of thin-walled cells that are flattened and form a simple squamous epithelium. This structural adaptation is crucial for the reabsorption processes that occur in the nephron.

In the case of the proximal convoluted tubule, distal convoluted tubule, and collecting duct, these structures have a more robust epithelial lining. The proximal convoluted tubule is lined with cuboidal epithelial cells that are highly active in reabsorption. The distal convoluted tubule also contains cuboidal cells but with fewer microvilli compared to the proximal tubule, and the collecting duct has columnar epithelial cells that regulate water and electrolyte balance. These differences in structure highlight the specialized functions of each part of the nephron, reinforcing why the thin ascending limb stands out as the segment without a consistent epithelial cell structure throughout.