What is the primary function of Pyruvate dehydrogenase?

The primary function of pyruvate dehydrogenase is to decarboxylate pyruvate to acetyl CoA. This enzyme catalyzes the oxidative decarboxylation of pyruvate, which is the end product of glycolysis, converting it into acetyl CoA, releasing carbon dioxide in the process. This reaction is crucial as acetyl CoA then enters the citric acid cycle (Krebs cycle) for further energy production.

The conversion of pyruvate to acetyl CoA is an essential link between glycolysis and the citric acid cycle. It not only serves as a bridge in cellular respiration but also plays a significant role in regulating energy metabolism. The formation of acetyl CoA is particularly important because it can be utilized in multiple metabolic pathways: for energy production via the citric acid cycle, in the synthesis of fatty acids, and in the production of ketone bodies.

The other options do not accurately represent the primary function of pyruvate dehydrogenase. For instance, the conversion of pyruvate to lactate occurs under anaerobic conditions and is catalyzed by lactate dehydrogenase, not pyruvate dehydrogenase. Facilitating glycolysis relates