GLUT 4 is stimulated by which hormone?

GLUT 4 is a glucose transporter located primarily in adipose tissues and striated muscles (skeletal and cardiac). It plays a crucial role in glucose homeostasis by facilitating the uptake of glucose from the bloodstream into these tissues. The primary hormone that stimulates this process is insulin.

Insulin, released by the pancreas in response to elevated blood glucose levels, promotes the translocation of GLUT 4 vesicles to the cell membrane, increasing the number of GLUT 4 transporters available for glucose uptake. This action helps decrease blood sugar levels by enhancing the cells' ability to take up glucose for energy production or storage.

In contrast, hormones like adrenaline (or epinephrine), glucagon, and cortisol are associated with increasing blood glucose levels or promoting glucose production in the liver rather than facilitating glucose uptake into muscle and adipose tissues. Adrenaline stimulates glycogen breakdown and glucose release into the bloodstream during stress responses. Glucagon primarily functions to increase blood glucose levels by promoting gluconeogenesis and glycogenolysis in the liver. Cortisol, a glucocorticoid, also contributes to elevating blood glucose levels during stress by promoting gluconeogenesis and inhibiting the actions of insulin.

Thus, the reason insulin is the correct answer